Pseudohypopyon is a relatively rare manifestation of leukemia. It occurs most often in patients with acute lymphoblastic leukemia and may be seen during a blast crisis or as a sign of relapse . Rapid development of an atypical, blood-stained hypopyon that fails to respond to corticosteroid therapy is classic for leukemic pseudohypopyon . Pseudohypopyon is distinguished from infectious or inflammatory hypopyon by the absence of an associated fibrin reaction. This pseudohypopyon was the first sign of this 56-year-old patient's acute lymphoblastic leukemia relapse. Timely anterior chamber aspiration with cytology and systemic malignancy work-up are paramount to ensuring appropriate diagnosis and treatment.
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