Aqueous misdirection is also known as malignant glaucoma, vitreous block glaucoma, ciliary block glaucoma, ciliolenticular glaucoma, or ciliovitreal block glaucoma.September 26, 2016
Left-sided headache and eye pain
History of Present Illness
An 88-year-old hyperopic female presented with left eye pain rated 10/10 and associated blurred vision, headache, nausea, and vomiting. The pain started approximately 4 hours previously and progressively became worse. She denied other ocular symptoms including tearing and photophobia. The patient had a history of cataract extraction with intraocular lens placement and Nd:YAG (neodymium: yttrium aluminium garnet) capsulotomy bilaterally. She also had a history of having a laser procedure previously for an unknown diagnosis.
Past Ocular History
- Pseudoexfoliation syndrome
Past Ocular Surgery
- Cataract extraction with posterior chamber intraocular lens OU (more than 5 years previously)
- Nd:YAG laser capsulotomy OU (approximately 1 year previously)
- Unknown laser procedure (more than 10 years previously)
Past Medical History
- Chronic pain
- Iodine contrast
Ocular Family History
- Former smoker
- Uses occasional alcohol
Review of Systems
- Per HPI, Otherwise negative
- Distance without correction
- Right eye (OD): 20/30 -1
- Left eye (OS): 20/600
- Distance with correction
- OS: 20/60
- Near card without correction
- OD: 20/25
- OS: 20/160
Ocular Alignment and Motility
- Orthotropic with full motility OU
Intraocular Pressure (IOP)
IOP measured by Tonopen®
- OD: 11 mmHg
- OS: 50 mmHg
- OD: 518 μm
- OS: 551 μm
- OD: 3 mm in dark → 2 mm in light; brisk but minimal reaction to light
- OS: 5 mm in dark → 5 mm in light; no reaction to light. 0.9 log unit relative afferent pupillary defect (RAPD)
- Lids/Lashes: Normal
- Conjunctiva: Clear and quiet
- Cornea: Clear
- Anterior chamber: Quiet and deep
- Iris: Normal
- Lens: Posterior chamber intraocular lens with open posterior capsule
- Vitreous: Normal
- Lids/Lashes: Normal
- Conjunctiva: 1+ injection
- Cornea: Clear
- Anterior chamber: Shallow anterior chamber with 2 corneal thickness depth centrally and peripheral iridocorneal apposition
- Iris: Peripheral iridotomy located at 10:30
- Lens: posterior chamber intraocular lens with open posterior capsule
- Vitreous: Normal; no cell
- Disc: Normal, peripapillary atrophy
- Cup to disc ratio 0.45
- Macula: Normal
- Vessels: Normal
- Periphery: Normal
- Disc: inferior notch, peripapillary atrophy
- Cup to disc ratio 0.75
- Macula: Normal
- Vessels: Normal
- Periphery: Normal
- OD: D35f1+ in all directions
- OS: A(A)25b in all directions
Standardized ocular echography left eye
- Mild vitreal opacities seen. Severe excavation of optic nerve. No retinal detachment or mass lesion was visualized.
Multiple rounds of topical dorzolamide/timolol, brimonidine, and latanoprost were given to this patient in the emergency room. Additionally, she received dilating drops and intravenous acetazolamide. Her intraocular pressure declined to the low 30's and the anterior chamber started to deepen in the emergency room. She was seen in the eye clinic the following morning. At that time, the anterior chamber had again shallowed and the IOP returned to mid 40's OS by applanation. The patient received four additional rounds of topical dorzolamide/timolol, brimonidine, latanoprost, and atropine, in addition to immediate release acetazolamide. The IOP was unresponsive, and a pars plana vitrectomy with Ahmed Seton was performed. The day after the procedure, the patient had resolution of headache and eye pain OS. The intraocular pressure was found to be 5. Unfortunately, the intraocular lens had dislocated posteriorly in the postoperative setting, likely secondary to pseudoexfoliation, but vision with +10D lens and pinhole was in 20/40 range. She elected to defer additional surgery at this time.
DIAGNOSIS: Aqueous Misdirection
Differential Diagnosis of flat or shallow anterior chamber and elevated IOP
- Aqueous misdirection
- Pupillary block
- Choroidal effusion/hemorrhage/mass lesion
- Hemorrhagic, Appositional/Kissing Choroidal Detachment
- Serous, Appositional/Kissing Choroidal Detachment
- Ciliary body rotation
- Hypotony with applanation of crystalline lens
Aqueous misdirection is a form of secondary glaucoma, related to pressure buildup from trapping of aqueous within the vitreous. It typically presents with diffuse shallowing (both central and peripheral) of the anterior chamber in the setting of elevated intraocular pressure, and is considered a diagnosis of exclusion (1, 2).
Aqueous misdirection typically occurs after correctional surgery for angle closure glaucoma. These patients usually have a history of angle closure or peripheral anterior synechiae (3). Aqueous misdirection has infrequently been associated with trauma, inflammation, or an unknown cause (4-6). It may occur days to months postoperatively; one study found median time to diagnosis was 33 days (7).
Aqueous misdirection occurs when aqueous is directed posteriorly and becomes trapped within the vitreous (8). This causes compression of the anterior vitreous making it more impermeable to aqueous (6, 9). This impermeability decreases the ability of the aqueous to flow freely forward through the posterior chamber to the anterior chamber, which leads to further trapping of aqueous in the posterior segment (8). The mechanism by which aqueous initially becomes directed posteriorly and trapped is unknown, though many theories have been proposed (9).
The key features that distinguish aqueous misdirection from similar diagnoses are diffuse shallowing of the anterior chamber (thus absent iris bombe), anterior displacement of the lens-iris diaphragm and a posterior segment free of hemorrhage, masses, or vein occlusion (6). A patent iridotomy/iridectomy in the setting of a flat or shallow anterior chamber is another clue to this diagnosis (4).
Distinguishing aqueous misdirection from other clinical entities can be difficult. Pupillary block presents with a deep central anterior chamber with a shallow periphery, and does not appear in the presence of a patent iridotomy (4, 6). Pupillary block may be either primary (the most common mechanism of primary angle closure glaucoma) or secondary. Major secondary etiologies include ectopia lentis, cataractous lens intumescence, aphakia/pseudophakia with dislocated intraocular lens, pupillary capture by intraocular lens implant, or posterior synechiae. Pupillary block is uncommon after surgery for angle closure glaucoma.
Anterior rotation of the ciliary body due to swelling, inflammation, medications, or masses can also cause a shallow anterior chamber. Additional testing, such as echography and anterior segment imaging, can be used to look for masses or effusions causing the anterior movement of the ciliary body.
Suprachoroidal hemorrhage is associated with severe eye pain, and hemorrhage will be detected either by dilated fundus exam or with echography (6). The absence of such on B-scan ultrasonography rules out suprachoroidal hemorrhage (1).
Finally, hypotony may be deceptive because it can present with a shallow anterior chamber and the lens may be opposed to the cornea causing artificial elevation of intraocular pressure (6, 10). This entity should be distinguishable from the others simply by palpation of the eye, revealing a hypotonous globe.
B-scan ultrasonography is useful to rule out other causes of flat anterior chamber such as choroidal effusions, suprachoroidal hemorrhage, and masses (1). High-resolution ultrasound biomicroscopy may assist in diagnosis by demonstrating anterior displacement of the lens-iris diaphragm, and possibly even anterior rotation of the ciliary body, ciliary processes, and/or zonules (5).
The first line treatment is medical therapy consisting of cycloplegics and aqueous suppressants (1, 3). Cycloplegia is the most important treatment as it moves the iris-lens diaphragm posteriorly in addition to relieving iris-lens apposition with dilation. A typical regimen includes atropine 1% four times a day (8). Aqueous suppressants include beta blockers, alpha 2 agonists, and oral and topical carbonic anhydrase inhibitors. Osmotic agents can be used to shrink the vitreous (3, 8). Cholinergics should be avoided as these medications tend to shift the lens-iris diaphragm forward. It is possible for up to 50% of cases to be relieved using such a regimen for 5 days, after which the medications may be tapered. However, recurrence is common, and a more definitive treatment may be necessary (8). Other potential treatment options include Nd:YAG laser therapy for aphakic and pseudophakic patients to disrupt the anterior vitreous face.
A pars plana vitrectomy is considered the definitive treatment (1, 3, 11). Removal of the anterior hyaloid is the most critical part of this surgery in order to prevent recurrence (8). Pars plana lensectomy should be added if damage to the crystalline lens occurs or if it is not possible to deepen the anterior chamber by vitrectomy and anterior hyaloidectomy alone (1, 8). Prophylactic pars plana vitrectomy may be considered during intraocular surgery for the fellow eye of a patient with a prior history of aqueous misdirection (12).
Summary: Aqueous Misdirection
Iowa glaucoma curriculum video on aqueous misdirection: http://curriculum.iowaglaucoma.org/chapter/19
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- Kaplowitz K, Yung E, Flynn R, et al. Current concepts in the treatment of vitreous block, also known as aqueous misdirection. Surv Ophthalmol. 2015;60(3):229-41.
- Ophthalmology AAO. Aqueous Misdirection. Basic and Clinical Science Course: Section 10, 2015-2016 Glaucoma. San Francisco: AAO; 2015. p. 131-3.
- Foreman-Larkin J, Netland PA, Salim S. Clinical Management of Malignant Glaucoma. J Ophthalmol. 2015;2015:283707.
- Shen CJ, Chen YY, Sheu SJ. Treatment course of recurrent malignant glaucoma monitoring by ultrasound biomicroscopy: a report of two cases. Kaohsiung J Med Sci. 2008;24(11):608-13.
- Alward WLM. Aqueous Misdirection. Iowa Glaucoma Curriculum. Updated March 2016. Cited June 30, 2016.; Available from http://curriculum.iowaglaucoma.org/chapter/19/video/191.
- Greenfield DS, Tello C, Budenz DL,et al. Aqueous misdirection after glaucoma drainage device implantation. Ophthalmology. 1999;106(5):1035-40.
- Ramulu PY, Gedde SJ. Aqueous Misdirection. In: Shaarawy TM, Sherwood MB, Hitchings RA, Crowston JG, editors. Glaucoma. London: Elsevier; 2015. p. 836-46.
- Epstein DL, Hashimoto JM, Anderson PJ, et al. Experimental perfusions through the anterior and vitreous chambers with possible relationships to malignant glaucoma. Am J Ophthalmol. 1979;88(6):1078-86.
- Liebmann JM, Weinreb RN, Ritch R. Angle-closure glaucoma associated with occult annular ciliary body detachment. Arch Ophthalmol. 1998;116(6):731-5.
- Bitrian E, Caprioli J. Pars plana anterior vitrectomy, hyaloido-zonulectomy, and iridectomy for aqueous humor misdirection. Am J Ophthalmol. 2010;150(1):82-7.e1.
- Chaudhry NA, Flynn HW, Jr., Murray TG, et al. Pars plana vitrectomy during cataract surgery for prevention of aqueous misdirection in high-risk fellow eyes. Am J Ophthalmol. 2000;129(3):387-8.
- Nguyen QH, Budenz DL, Parrish RK, 2nd. Complications of Baerveldt glaucoma drainage implants. Arch Ophthalmol. 1998;116(5):571-5.
- Olayanju JA, Hassan MB, Hodge DO, et al. Trabeculectomy-related complications in Olmsted County, Minnesota, 1985 through 2010. JAMA ophthalmology. 2015;133(5):574-80.
- Jampel HD, Musch DC, Gillespie BW, et al. Perioperative complications of trabeculectomy in the collaborative initial glaucoma treatment study (CIGTS). Am J Ophthalmol. 2005;140(1):16-22.
- Gedde SJ, Schiffman JC, Feuer WJ, et al. Three-year follow-up of the tube versus trabeculectomy study. Am J Ophthalmol. 2009;148(5):670-84.
Suggested citation Format
Evans JA, Haugsdal JM, Alward WLM. Aqueous Misdirection. EyeRounds.org. September 26, 2016; Available from: http://EyeRounds.org/cases/244-Aqueous-Misdirection.htm