Atlas Entry - Acute posterior multifocal placoid pigment epitheliopathy (APMPPE)

Acute posterior multifocal placoid pigment epitheliopathy (APMPPE)

Category(ies): Retina, Vitreous, Uveitis

Contributor: Angela McAllister, MD

Photographer: Brice Critser, CRA

APMPPE is one of the white dot syndromes that occurs in young healthy adults and similarly affects males and females. It is usually bilateral, although may be worse in one eye. APMPPE is generally a self-limited condition that requires no treatment and has a good prognosis.

A 47-year-old female presents with a four day history of fluttering bright spots in the right eye. She denies a viral prodrome or headaches.

fundus image, yellow-white lesions throughout the macula — Color fundus photo, right eye (OD): Multiple creamy yellow-white lesions throughout the macula. There is mild vitritis on exam and mild disc edema.

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OCT — Optical coherence tomography OD: Disruption of the outer retinal layers.

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Laminar phase of fluorescein angiogram demonstrating early hypofluorescence of the lesions

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Late phase of fluorescein angiogram demonstrating late staining of lesions

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Acute posterior multifocal placoid pigment epitheliopathy (APMPPE)

Category(ies): Retina / Vitreous,Uveitis

Contributor: Mahsaw Mansoor, MD

Photographer: Jody Troyer, CRA

Posted: 06/04/2024

A 36-year-old woman presented with progressive vision loss in both eyes following a viral infection. On exam, there were placoid areas of whitening throughout the posterior pole of both eyes. On fluorescein angiography, the lesions on exam demonstrated early blocking defects and late staining.