Acute Macular Neuroretinopathy (AMN)
Contributor: Christopher Kirkpatrick, MD
Photographer: Antoinette Venckus, CRA
Acute macular neuroretinopathy (AMN) is a rare disease of unknown etiology that most commonly affects young to middle-aged females. The patient typically presents with the acute-onset of one or multiple paracentral scotomas that affect one or both eyes. This is typically the only symptom and visual acuity is unaffected. Fundus findings include 1 or more reddish-brown petalloid perifoveal lesions with the tip pointed toward the fovea that become visible days to months after the onset of symptoms. Lesions are typically better identified with infrared imaging. OCT through the lesions commonly show disruption of the inner segment/outer segment (IS/OS) junction (ellipsoid zone). There is no known treatment and symptoms may not resolve.
Bhavsar KV, Lin S, Rahimy E, Joseph A, Freund KB, Sarraf D, Cunningham ET Jr. Acute macular neuroretinopathy: A comprehensive review of the literature. Surv Ophthalmol. 2016 Sep-Oct;61(5):538-65. http://pubmed.gov/26973287.
Contributor: James M. Coombs, MD
Feb 8, 2008
44-year-old female with acute onset of paracentral scotomas in right eye (corresponded directly to Amsler grid findings)
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