University of Iowa Health Care

Ophthalmology and Visual Sciences

Graft-host interface candida infection after descemet stripping automated endothelial keratoplasty

Contributor: Angela McAllister, MD

Candida at grat-host interface

This patient had a history of Fuchs' endothelial dystrophy. He underwent a descemet stripping automated endothelial keratoplasty (DSAEK) of the right eye. The donor cornea rim was cultured and found to be positive for candida. Despite treatment with topical amphoteracin B and oral fluconazole the patient developed infiltrates between the graft and host cornea. He had a repeat DSAEK with intracameral voriconazole. The pathology from the initial graft tissue confirmed budding yeast. Unfortunately, the candida returned in the subsequent graft host interface and the patient ultimately underwent full thickness cornea transplant.

This photo shows four small infiltrates present in the graft host interface of the right eye.

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last updated: 07/31/2013
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