Cyanoacrylate adhesive for corneal perforation secondary to peripheral ulcerative keratitis (PUK)
Contributor: Jesse Vislisel, MD
Photographer: Stefani Karakas, CRA
Cyanoacrylate adhesive is a synthetic compound that rapidly polymerizes upon contact with the dry ocular surface. It is useful to temporarily provide tectonic support for ocular perforations up to 2-3 mm in diameter and has been demonstrated to have antibacterial properties (1). The top photographs show the appearance of a patient upon presentation with peripheral ulcerative keratitis in the setting of poorly-controlled rheumatoid arthritis. The severe corneal thinning continued to progress despite medical therapy, resulting in corneal perforation. The bottom photographs show the appearance after stabilization with cyanoacrylate adhesive and several days of oral prednisone and doxycycline.
Reference: (1) Eiferman RA, Snyder JW: Antibacterial effect of cyanoacrylate glue. Arch Ophthalmol. 1983;101:958-960. PMID: 6683097