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Ophthalmology and Visual Sciences

Dominant optic atrophy

Dominant optic atrophy

Category(ies): Inherited Eye Disease, Neuro-Ophthalmology
Contributor: Jesse Vislisel
Photographer: Cindy Montague, CRA

Dominant optic atrophy (Kjer syndrome), the most common inherited optic neuropathy, is an autosomal dominant condition caused by a mutation in the OPA1 gene. The condition typically results in mild to moderate bilateral vision loss with an insidious onset beginning in childhood. Note the symmetric temporal wedges of disc pallor in the photographs.