Leukocoria is the most common sign associated with retinoblastoma. Leukocoria is present in over half of all infants presenting with retinoblastoma. Other conditions may also be associated with leukocoria as a presenting symptom, including: congenital malformations (e.g. persistent hyperplastic fetal vasculature); tumors (e.g. medulloepithelioma); vascular diseases (e.g. retinopathy of prematurity); inflammatory diseases (e.g. ocular toxocariasis); trauma (e.g. vitreous hemorrhage).
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