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Ophthalmology and Visual Sciences

Retinoblastoma causing leukocoria

Retinoblastoma causing leukocoria

Category(ies): Pediatrics, Retina, Vitreous
Contributor: Jesse Vislisel, MD
Updated and Expanded by: Cameron Wagner, BS and Lorraine M. Provencher, MD

Leukocoria is the most common sign associated with retinoblastoma. Leukocoria is present in over half of all infants presenting with retinoblastoma. Other conditions may also be associated with leukocoria as a presenting symptom, including: congenital malformations (e.g. persistent hyperplastic fetal vasculature); tumors (e.g. medulloepithelioma); vascular diseases (e.g. retinopathy of prematurity); inflammatory diseases (e.g. ocular toxocariasis); trauma (e.g. vitreous hemorrhage).

Leukocoria is present in over half of all infants presenting with retinoblastoma
This child presented after the parents noted the rapid development of leukocoria in the left eye and was found to have unilateral retinoblastoma without metastasis.
MRI retinoblastoma
The MRI image shows the extent of the tumor within the left globe.
  • Balmer A, Munier F. 2007. Differential diagnosis of leukocoria and strabismus, first presenting signs of retinoblastoma. Clinical Ophthalmology. 1(4):431-439.

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