University of Iowa Health Care

Ophthalmology and Visual Sciences

X-linked retinoschisis (XLRS)

Contributor: Jesse Vislisel, MD

Photographer: Stefani Karakas, CRA

X-linked retinoschisis (XLRS) is an X-linked recessive condition caused by a mutation in the RS1 gene. It results in splitting of the foveal and sometimes peripheral neurosensory retina. Clinically, this appears as cystic spaces and radial striae in the central macula, as seen in these photographs. The splitting is even more apparent on OCT. Over time, patients with XLRS develop decreased acuity with a central scotoma as seen in these Goldmann visual fields.

click any image for higher resolution

Right eyeleft eyeRight eyeleft eyeRight eyeleft eye

Creative Commons License
Ophthalmic Atlas Images by, The University of Iowa are licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.

last updated: 11/5/2013
Share this page: