55-year-old male with history of schizophrenia and long term chlorpromazine use. There is blue-gray dyspigmentation of the nose, bilateral cheeks, forearms, dorsal hands and arms in photo-distributed areas. Slit lamp examination shows diffuse punctate corneal deposits through the posterior stroma, descemet membrane, and endothelium of the cornea.
Corneal and lenticular pigmentation from long-term chlorpromazine use
59-year-old male with history of schizophrenia and long-term chlorpromazine (thorazine) treatment. His ocular exam is notable for fine pigment deposition in the posterior corneal stroma and endothelium. In addition, there is pigmentation in a stellate pattern on the anterior lens and lens capsule. This rarely causes a decrease in visual acuity.
These findings are characteristic of long-term thorazine use and are suspected to be related to dose and duration of treatment. It is recommended that persons undergoing long-term treatment with thorazine have regular eye examinations.
Ophthalmic Atlas Images by EyeRounds.org, The University of Iowa are licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
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