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Ophthalmology and Visual Sciences

Primary acquired melanosis (PAM)

Primary acquired melanosis (PAM)

Category(ies): Cornea
Contributor: Jesse Vislisel, MD
Photographer: Brice Critser

Primary acquired melanosis (PAM) is an acquired pigmentation of the conjunctival epithelium. It is analagous to lentigo maligna of the skin and carries a risk of malignant transformation. PAM appears as unilateral, patchy areas of flat, brown pigmentation within the superficial conjunctiva. The areas may wax and wane over time.


Primary Acquired Melanosis (PAM)

Primary Acquired Melanosis (PAM)

Category(ies): Cornea / External Eye Disease
Contributor: Lauren A. Tomlinson MD; Ryan J. Diel MD
Photographer: Michael T. Edrington
Posted: 06/02/2025

66 year old Caucasian male with one flat clock hour of conjunctival pigmentation inferiorly from 6 to 7 o’clock on the right eye. Pigment extended to the limbus. No feeder vessels were identified. Gonioscopy showed no evidence of ciliary body tumor. The patient first noticed this spot two weeks prior to presentation. These findings were consistent with primary acquired melanosis (PAM). Two small iris nevi were also seen inferiorly, above the area of PAM. A small lower lid margin nevus measuring 1.5 mm was identified nasally on the same eye. As no concerning features were identified on examination, annual surveillance including repeat slit lamp photography was advised to monitor for progression.

Slit lamp photography showing one clock hour of flat, brown pigmentation localized inferiorly and extending superiorly to the limbus of the right eye. Two small iris nevi can be seen superior to the area of PAM.
Slit lamp photography showing one clock hour of flat, brown pigmentation localized inferiorly and extending superiorly to the limbus of the right eye. Two small iris nevi can be seen superior to the area of PAM.
Slit lamp photography illustrating that the area of pigmentation is flat on narrow white light beam illumination.
Slit lamp photography illustrating that the area of pigmentation is flat on narrow white light beam illumination.
Slit lamp photography showing PAM, two iris nevi, and a 1.5 mm lower lid margin nevus nasally.
Slit lamp photography showing PAM, two iris nevi, and a 1.5 mm lower lid margin nevus nasally.