Allergic Contact Dermatoblepharitis
December 22, 2009
Chief Complaint: Itchy eyes and blurry vision OU
History of Present Illness: A 55-year-old female with a Medical History significant for multiple sclerosis presented to our Comprehensive Ophthalmology clinic with a one-week history of itchy eyes and blurry vision. She had started using a new facial cleanser about two days prior to the onset of these symptoms. She had discontinued it one day before presentation and had not yet noticed any improvement.
Past Ocular History: Optic neuritis due to Multiple Sclerosis diagnosed in 2002, LASIK OU, dry eyes OU, amblyopia OS
Medical History: Multiple Sclerosis, hyperlipidemia, HTN, low back pain, GERD, hyothyroidism.
Medications: Refresh AT, simvastatin, hydroxyzine, baclofen, amantidine, omeprazole, levothyroxine
Family History: No family history of eye disease.
Social History: Denies tobacco or alcohol use.
Review of Systems: Negative except for what is described in History of Present Illness.
General: Normal body habitus, in no acute distress
Visual Acuity: OD 20/20-1 OS: 20/50
Pupils: OD: 4mm to 2mm, OS: 4mm to 2mm. No RAPD
Intraocular pressure: OD: 12 mm Hg, OS: 13 mm Hg
Anterior Segment exam: No preauricular lymphadenopathy
Lids and Lashes: Erythematous, thickened and scaly skin OU (Figure 1)
Conjunctiva: Minimal erythema, few papillae
Cornea: LASIK flap OU, diffuse punctate epithelial erosions OU, confluent centrally. Tear film break-up time < 10 sec OU
Anterior Chamber: No cell or flare OU
Iris: Normal architecture OU
Lens: Trace nuclear sclerosis OU.
Anterior Vitreous: Quiet OU
Dilated Fundus Exam:
- Optic Nerve: Pink, sharp borders OU
- Macula, vasculature and periphery normal OU
In this patient, there is a clear history of new-onset of itchy eyes that accompanied the introduction of a new cosmetic product which is suggestive of allergic disease, or allergic contact dermatoblepharitis. Seborrheic dermatitis is a possibility given the patient's scaly lesions; however, it is often a chronic and recurrent disease and the skin is often greasy. Contact urticaria is also in the differential, however it presents within 30 minutes to an hour after exposure. Atopic dermatitis is also in the differential, but this tends to present in individuals who have a personal history of asthma, allergic rhinitis, or eczema, and this patient had none of these. Skin lesions for rosacea and psoriasis are different in appearance from the lesions in this patient. (2)
The patient had already stopped the use of her new facial cleanser, and was instructed not to use it again. She was prescribed artifical tears and hydrocortisone 1% cream bid for a few days. Upon follow-up by telephone, the patient stated that her symptoms had completely resolved.
Allergic contact dermatoblepharitis is the result of an allergic response to an ophthalmic medication, cosmetics, or environmental substances. It is most commonly a delayed type IV hypersensitivity reaction that presents 24 to 72 hours after exposure, after sensitization of T-lymphocytes to an antigenic substance.(1,2)
Medications commonly associated with allergic contact dermatoblepharitis include cycloplegics (atropine, homatropine), aminoglycosides (neomycin, gentamicin, tobramycin), antiviral agents (trifluridine, idoxuridine), and preservatives (thimerosal and EDTA). There are over 300 documented triggers, and common ones are summarized in table 1. These include cosmetics (products used for the eyelids, hands, face, and hair), metals (nickel, cobalt, gold), and fingernail products (base coats lacquer, and sealer). (1,3,4).
One of the hallmarks of the clinical presentation is pruritus of the eyelids. The eyelid develops an acute eczema with erythema, leathery thickening, and scaling of the eyelid. (See figure 1) There may be involvement of the conjunctiva, and punctate epithelial erosions may be noted on the cornea.(1,2) Management of allergic contact dermatoblepharitis begins with removal of the offending agent. Identification of the agent can often be determined from the history, but occasionally a challenge of the agent is required. This should never be done with a person known to have a systemic allergy to a drug. In cases where an offending agent is not easily identified, patch testing can be helpful. In cases where suspected products are not known to ordinarily create skin irritation, a "use test" may be applied. To conduct this test, an implicated item is applied as is, twice a day to a 1cm x 1 cm site on the flexor forearm, back of the ear, or neck for five days. This site is then inspected for dermatitis.(5)
Supportive treatment with cold compresses and artificial lubricants is adequate in most cases. Adjunctive therapy may involve the use of cold compresses, topical antihistamines (such as azelastine for instantaneous relief of itching), mast-cell stabilizers, or topical nonsteroidal anti-inflammatory agents (in the case of pain). In severe cases, a brief (several day) course of hydrocortisone 1% may speed resolution. Topical corticosteroids should be used sparingly to avoid thinning of the eyelid skin.(1,2). Another option is topical immunomodulators, such as pinecrotimus cream (Elidel) applied to the lid twice a day.(6)
- Sutphin, et al. External Disease and Cornea. Basic and Clinical Science Course Section 8, 2009-2010. American Academy of Ophthalmology, Singapore, pp. 205-207.
- Peralejo, B., V. Beltrani, et al. Dermatologic and allergic conditions of the eyelid. Immunol Allergy Clin North Am 2008;28(1): 137-68, vii.
- Guin, J. D. Eyelid dermatitis: experience in 203 cases. J Am Acad Dermatol 2002;47(5): 755-65.
- Rietschel, R. L., E. M. Warshaw, et al. Common contact allergens associated with eyelid dermatitis: data from the North American Contact Dermatitis Group 2003-2004 study period. Dermatitis 2007;18(2): 78-81.
- Zug, K. A., D. A. Palay, et al. Dermatologic diagnosis and treatment of itchy red eyelids. Surv Ophthalmol 1996;40(4): 293-306.
- Roy, F. H. Itchy Eyelids. Ann Ophthalmol 2007;39(3): 183-4.
Suggested Citation Format: Shah SS. Oetting TA. Allergic Contact Dermatoblepharitis. EyeRounds.org. December 23, 2009; Available from: http://www.EyeRounds.org/cases/80-Dermatoblepharitis.htm