A 68-year-old male patient presented for a routine cataract evaluation and was found to have a suspicious conjunctival lesion in the left eye. He reports symptoms of foreign body sensation, itching, and extreme ocular dryness (notably frequent blinking). The patient has a known history of cryotherapy for precancerous skin lesions on the face. On the exam, the best-corrected visual acuity was 20/20 in both eyes with intraocular pressures of 19 mmHg OD and 20 mmHg OS. Extraocular movements and visual fields were full bilaterally. Slit lamp exam of the left eye revealed a nasal, elevated, gelatinous conjunctival lesion with leukoplakic areas extending approximately 1 mm onto the cornea, along with a temporal pinguecula and prominent nasal vessels. The patient underwent conjunctival biopsy of the left eye, and histopathology revealed a moderately differentiated squamous cell carcinoma in situ with positive margins. The patient underwent 6 rounds of topical chemotherapy therapy with Fluorouracil (5-FU).
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